Located in the middle reaches of the Glang-chen River basin, the Gad pa Ser rul Cemetery is one of the earliest tombs discovered in western Xizang. A large number of talc beads were unearthed from the tombs. In this study, a series of non-destructive analytical techniques such as gem microscopy, Raman spectrometry, X-ray diffraction, scanning electron microscopy-energy dispersive spectrometry were used, to obtain the chemical composition, phase structure and surface appearance of the talc beads. The results show that the disc-shaped perforated talc beads unearthed from the Gad pa Ser rul Cemetery were probably made of block talc after heat treatment. This work could provide important information for enriching the research data of early beading in western Xizang, and understanding the communication of ancient people in western Xizang and their social and cultural life.