Due to the characteristics of relatively enclosed museum space, the presence of crowds, the coexistence of people and cultural relics, etc., both people (staff and visitors) and objects (culture relics or artworks) should be considered when disinfectants are used. In terms of measures for people, the document, Guidelines for the Use of Disinfectants, has adequately explained the scope of precautions to be taken when using disinfectants. The discussion in this paper focuses only on three aspects of measures to be taken for culture relics:1) classification of cultural relic materials from the perspective of their scientific and technological conservation; 2) classification of disinfectants according to active ingredients, and significant chemical characteristics of disinfectants that may damage cultural relics and 3) mechanisms of damage and the consequences of using disinfectant on cultural relics. In the special stage of epidemic prevention and control, museum staff must have a comprehensive understanding of the characteristics of various disinfectants in order to ensure the safety of cultural relics. Using disinfectants in a rational and regulated way and preventing improper use from causing damage to cultural relics are essential tasks for the preventive conservation of culture relics.