To make up for the lack of research on conservation materials for murals in humid areas of south China, we evaluated the conservation effects of some materials used for mural surface reinforcement and fracture grouting under a simulated climatic condition of south China. Through evaluations of surface gloss, water resistance, aging resistance and other properties, we found that 1) 1.5% (mass fraction) RS1930 pure acrylic emulsion had better surface-reinforcing effect and 2) traditional lime added with ZB-SE-3A pure acrylic emulsion (about 3% of lime mass) and nano materials (about 2% of lime mass) demonstrated good strength, mildew resistance, water resistance and aging resistance, and was suitable as a fracture-grouting material for murals in humid areas.