The underground storerooms of the Palace Museum were built in 1986. After many years, earthquake prevention has become an outstanding issue of the storerooms. Based on the difficulties that would be encountered in reconstruction of the underground storerooms, a more suitable solution to the seismic problem has been proposed. The plan is to utilize a seismic isolation device composed mainly of chucks, guide-bars and damping plates, that is simple in structure and easy to install. In order to evaluate its effectiveness, we created a finite element analysis model and selected three seismic waves for time-history analysis. The results show that 1) the independent, unprotected storage cabinets in these storerooms have poor seismic performance, in that they sway violently and even overturn under the condition of a 9-degree rarely-occurring earthquake; 2) when using the anti-seismic device, the sway amplitude of the combined double cabinets decreases significantly as a result of increasing the sliding distance to dissipate the seismic energy, giving the maximum amplitude of only 1.64° (El Centro wave). Therefore, the analysis results demonstrate the seismic effectiveness of the device.