The Maritime Silk Road in the Han Dynasty connected Lingnan area of southern China, Southeast Asia, South Asia and littoral areas of the Mediterranean by sea. As the region of ports of departure of the Han Maritime Silk Road, Lingnan area has great significance for studying the exchanges between China and foreign countries at that time. Glass beads are one of the most typical artifacts excavated from Han tombs in Lingnan area. This paper summarizes the glass types and techniques of manufacture of the glass beads, and discusses their provenances based on their chemical compositions and shapes. Furthermore, this work illuminates exchanges between China and other foreign countries. Glass beads found in Han tombs located in Lingnan area provide credible evidence of Sino-foreign exchanges and have important academic value and research significance.