The wall paintings in the Gansu Museum collection are of great historical, scientific and artistic value. Most of those wall paintings came from buried archeological sites; others came from grottos or ancient architectures. The materials (mud or lime ground layers) are fragile. These paintings usually have a long history of damage. Previous research suggested that watersalt migration in the wall was a main cause of wall painting deterioration. However, once they have been moved to the museum environment, the surrounding environment (e.g. temperature and humidity) of the wall paintings can be controlled and it is easier to protect them. In this paper the wall paintings at Gansu Museum was used, from Tiantishan grottoes, Wuwei, as an examples in order to discuss the conservation of wall paintings in a museum environment. With many years of wall conservation experience, the key procedures of intervention, retreading, and the exchange of support were focused on. Through practical exploration of conservation techniques and concepts, the authenticity and integration of wall paintings were preserved. It’s suggested that through the use multimedia, the process of conservation and the value of the paintings can be vividly enhanced, which is not done in traditional exhibits. The research provides reference for conservation of similar objects.