Since 1952, tomb murals that were removed and moved to museums have faced many risks in the processes of restoration, collection, display, transportation and research. What can be seen is moderate and even severe corrosion damage, such as extra-covering, color changing, powdering and falling off of the paint layer, detachment of the plaster layer, deformation of the support layer, etc. Thus there is urgent basic work to be done to sort out and investigate the risk factors that lead to the deterioration and damage of mural collections at this stage. Starting from the perspective of mural conservation, and fully considering the fragility of the mural itself, this article identifies potential uncertainties in collection management as clear risk factors. Targeted preventive measures are proposed to slow down the aging of mural collections and to avoid risks, and also to provide references for strengthening collection conservation and zero-risk management.