In the Palace Museum, there is only one set of gilded and stone-inlaid bronze five-sacrificial utensils, which is beautiful in shape and exquisite in workmanship. However, one pair of flower goblets was seriously injured, resulting in a large number of missing inlays. Before restoration, the structure, inlay materials and adhesive material of the goblets were analyzed using CT, Raman, XRF and IR. The results show that 1) the adhesive material is “wax glue”, the formula of which has been lost; 2) the green inlays are turquoise, and the indigo-blue inlays are potash-lime glass with cobalt as the colorant and lead as the flux. During restoration, modern substitutes for the traditional “wax glue”, turquoise and lead-free cobalt blue glass were selected as repair materials based on the testing results. Also, more than 700 pieces of inlays have been restored and patched in an accurate, fast and orderly way following the principle of “fine zoning” and “focusing first and then carving slowly”. This work could provide a typical case for the restoration of large mosaic cultural relics.