Due to the influence of preservation environment and man-made destruction, most ancient Chinese prints have different degrees of defects, and their artistic and research value have been seriously damaged. Therefore, with the aim of reproducing the artistic style of ancient printmaking, virtual restoration of a Buddhist print with seriously incomplete images, from Huachi County Museum of Gansu Province, was carried out using a series of technologies such as image acquisition, digital painting and art micro spray, based on the color management system. This work has shown that the digital Quanse (which is taken to make the works as completely perfect as what it used to be by coloring) and Jiebi (which is a special way to make the works complete by mending the defects) technology can accurately restore graphics and colors without interfering with the original cultural relic, and that the replica after virtual restoration could be used as an image supplement. When displayed together with the traditionally restored cultural relic, it can improve the artistic aesthetics. These research results may provide a reference for the development of calligraphy and painting conservation and restoration technologies.